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Table 2 Multivariable analysis of predictors for level IB LNs metastases at diagnosis in 1438 patients

From: Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis

Variable

HR

95 % CI

P *

Age, ≧50 years vs. <50 years

1.51

0.78–2.94

.219

T classification, T4 vs. T1-3

1.16

0.53–2.52

.708

Nasal cavity involvement, (+) vs. (−)

1.31

0.65–2.64

.446

Oropharynx involvement, (+) vs. (−)

2.59

1.18–5.69

.018

Positive RLNs, (+) vs. (−)

2.85

0.86–9.50

.088

Positive CLNs, (+) vs. (−)

2.53

0.80–8.01

.113

LN necrosis, (+) vs. (−)

1.22

0.59–2.52

.594

LNs with ES, (+) vs. (−)

0.57

0.27–1.19

.131

DLN-IIa ≥ 20 mm or level IIa LNs with ES, (+) vs. (−)

2.21

1.10–4.46

.026

MAD of LNs ≥30 mm, (+) vs.(−)

1.51

0.70–3.25

.293

Positive bilateral CLNs, (+) vs.(−)

1.95

0.97–3.92

.061

Positive CLNs at supraclavicular fossa, (+) vs. (−)

2.04

0.87–4.82

.103

  1. Abbreviations: LNs, lymph nodes; HR, hazard ratio; 95 % CI, 95 % confidence interval; RLNs, retropharyngeal lymph nodes; CLNs, cervical lymph nodes; D LN-IIa , greatest dimension of level IIa lymph nodes; MAD, maximal axial diameter; ES, extra-capsular spread
  2. *P-values were calculated using a binary logistic regression model