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Table 4 γ-H2AX intensity in CD45 + CD3+ lymphocytes, CD45 + CD14 + CD15- monocytes and CD45 + CD3-myeloid cells

From: The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Parameter

N

Before CT Day 0 Mean (SE)

30 minutes after CT Day 0 Mean (SE)

Increase

P value

CD45 + CD3+ lymphocytes

STF (n = 14)

75.5 (4.7)

89.5 (6.5)

↑

0.020

Non-STF (n = 6)

78.8 (5.6)

95.7 (5.9)

↑

0.001

CD45 + CD14 + CD15- monocytes

STF (n = 12)

162.2 (11.9)

192.5 (14.3)

=

0.055

Non-STF (n = 6)

180.8 (15.6)

206.2 (20.8)

=

0.051

CD45 + CD13- myeloid cells

STF (n =14)

104.0 (7.0)

109.5 (8.4)

=

0.594

Non-STF (n = 6)

109.0 (7.8)

123.0 (6.7)

↑

0.009

Parameter

N

Before CT Day 0 Median (range)

7 days after CT Median (range)

Increase

P value

CD45 + CD3+ lymphocytes

STF (n =16)

75.5 (49–157)

83.0 (64–141)

=

0.109

Non-STF (n = 9)

78.0 (47–102)

90.0 (71–114)

↑

0.015

CD45 + CD14 + CD15- monocytes

STF (n = 14)

157.0 (114–231)

186.5 (132–295)

↑

0.035

Non-STF (n = 8)

203.5 (116–273)

258.5 (183–319)

↑

0.021

CD45 + CD13- myeloid cells

STF (n = 16)

106.0 (71–173)

84.0 (65–145)

=

0.379

Non-STF (n = 9)

88.0 (49–137)

88.0 (74–119)

=

0.477

  1. Paired comparison between pre- and post- chemotherapy (30 minutes and 7 days; median of 6 cycles of TAC) for the different cell types. γ-H2AX intensity is given as mean and median depending on the distribution
  2. Bold value indicates that p < 0.05. 95 % CI; 95 % confidence interval. P values are given for differences of intensity of γ-H2AX between pre- and post-chemotherapy