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Fig. 8 | BMC Cancer

Fig. 8

From: Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Fig. 8

RT-qPCR validation and immunohistochemical evaluation of N-MYC in MYC translocation-positive and MYC translocation-negative BL primary tumors. a Quantitative-RT-PCR The expression of NMYC was analysed RT-qPCR. MYC-translocation negative cases show a dramatic hyper-expression of the gene; altogether RT-qPCR results confirmed the bioinformatics predictions, which suggest a regulation of these by the miR29 family. Over-expression of the selected genes is in accordance with down-regulation of the miR-29 family observed in MYC-translocation negative cases; (b-c) Immunohistochemistry. In the exemplifying MYC translocation-positive case (b), the staining is present only in 5 % of neoplastic cells in contrast to the MYC translocation-negative one (c), in which the positivity is detectable in about 90 % of cells. b: H&E, c: NMYC stain. b-c, O.M: 40x

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