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Fig. 7 | BMC Cancer

Fig. 7

From: Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Fig. 7

RT-qPCR validation and immunohistochemical evaluation of DNMT3B in MYC translocation-positive and MYC translocation-negative BL primary tumors. a Quantitative-RT-PCR The expression of DNMT3B was analysed at the mRNA level by RT-qPCR. As for DNMT3A, DNMT3B resulted up-regulated in cases lacking the translocation; (b-c) Immunohistochemistry. In the exemplifying MYC translocation-positive case (b), the staining is shown in 5 % of neoplastic cells in contrast to the MYC translocation-negative one (c), in which about 70 % of cells are positive. b-c: DNMT3B stain. O.M: 20x

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