Fig. 7From: Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulationRT-qPCR validation and immunohistochemical evaluation of DNMT3B in MYC translocation-positive and MYC translocation-negative BL primary tumors. a Quantitative-RT-PCR The expression of DNMT3B was analysed at the mRNA level by RT-qPCR. As for DNMT3A, DNMT3B resulted up-regulated in cases lacking the translocation; (b-c) Immunohistochemistry. In the exemplifying MYC translocation-positive case (b), the staining is shown in 5Â % of neoplastic cells in contrast to the MYC translocation-negative one (c), in which about 70Â % of cells are positive. b-c: DNMT3B stain. O.M: 20xBack to article page