Fig. 1

MYC mRNA and protein expression in MYC translocation-positive and -negative BL cases. a Quantitative-RT-PCR. The expression of MYC was analysed at the mRNA level in cases either carrying or lacking the translocation. RT-qPCR results show the up-regulation of the gene also in the absence of MYC translocation; (b-c) Immunohistochemistry. In the exemplifying MYC translocation-positive case (b), a strong staining in about 95 % of neoplastic cells is shown in contrast to the MYC translocation-negative one (c), in which the staining intensity was present in about 60 % of cells. b-c: MYC stain. Original Magnification (O.M): 20x