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Table 4 Methylation frequency (%) of SFRP CpG islands at different cutaneous SCC pathological levels

From: Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis

Gene

CpG Site

Stage I

Stage II

Stage III

H

P-value

N

\( \overline{x}\pm s \)

N

\( \overline{x}\pm s \)

N

\( \overline{x}\pm s \)

SFRP1

CpG1_5

0

0.4012 ± 0.098

0

0.4521 ± 0.115

9

0.4952 ± 0.109

6.157

0.024*

CpG1_7

9

0.4011 ± 0.134

6

0.4811 ± 0.024

2

0.5121 ± 0.124

5.103

0.031

CpG2_1

7

0.4141 ± 0.19

0

0.4267 ± 0.314

2

0.4013 ± 0.217

2.136

0.021

CpG2_8

5

0.4231 ± 0.824

7

0.4501 ± 0.224

4

0.5011 ± 0.523

8.514

0.017

SFRP2

CpG1_5

44

0.3329 ± 0.101

29

0.3796 ± 0.170

19

0.4241 ± 0.183

6.142

0.015

CpG2_1

47

0.4094 ± 0.036

48

0.4367 ± 0.316

17

0.4713 ± 0.107

6.136

0.023

CpG2_3.4

55

0.4017 ± 0.098

42

0.4406 ± 0.194

18

0.4891 ± 0.153

5.218

0.015

SFRP4

CpG1_3

2

0.3029 ± 0.089

3

0.3496 ± 0.012

2

0.3867 ± 0.083

7.158

0.009

CpG2_2

9

0.2994 ± 0.037

2

0.3367 ± 0.016

5

0.4113 ± 0.086

7.156

0.023

SFRP5

CpG1_5

40

0.3014 ± 0.052

33

0.3834 ± 0.021

18

0.4345 ± 0.037

5.54

0.031

CpG2_1

32

0.2941 ± 0.098

19

0.3167 ± 0.314

34

0.4013 ± 0.057

3.136

0.021

  1. N: number of samples; H: the Kruskal-Wallis H test
  2. *p ≤ 0.05 indicates statistical significance