Fig. 2
From: Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma
ATR kinase-dependent, Chk1 serine-345 phosphorylation was induced by gemcitabine in all cell lines. Exponentially dividing lung cancer cell lines were exposed to gemcitabine and ATR kinase inhibitor ETP-46464 (ATRi) or ATM kinase inhibitor KU55933 (ATMi) for 4 h. Whole cell extracts were prepared, resolved and immunoblotted as indicated