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Table 2 Association between clinical variables and objective response by RECIST

From: Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival

Variable

 

Total n

CR + PR n (%)

SD + PD n (%)

p value

Grade

1 + 2

74

42 (57)

32 (43)

0.01

3

9

1 (11)

8 (89)

Mucinous histology

no

84

46 (55)

38 (45)

0.048

yes

10

2 (20)

8 (80)

Liver metastasis

no

31

8 (26)

23 (74)

0.001

yes

64

40 (62)

24 (38)

Peritoneal metastasis

no

79

43 (54)

36 (46)

0.09

yes

16

5 (31)

11 (69)

Chemotherapy

FOLFIRI

52

25 (48)

27 (52)

0.43

FOLFOX

39

22 (56)

17 (44)

Hypertension

no

61

29 (47)

32 (53)

0.41

yes

30

17 (57)

13 (43)

Chemo + bevacizumab as first-line therapya

no

28

9 (36)

19 (64)

0.02

yes

67

40 (60)

27 (40)

  1. RECIST: Response Evaluation Criteria in Solid Tumors; FOLFIRI: infusional 5-fluoro-uracyl plus leucovorin plus irinotecan; FOLFOX: infusional 5-fluoro-uracyl plus leucovorin plus oxaliplatin; CR: Complete Response; PR: Partial Response; SD: Stable Disease; PD: Progressive Disease (PD). Data are number of patients and numbers in parentheses are percentages. aChemo: chemotherapy