Table 6 Univariate analysis with clinicopathological features in GC

Sex

Male

37/151(24.5)

44/146(30.1)

69/149(46.3)

60/143(41.9)

54/152(35.5)

Female

22/71(30.9)

25/68(36.8)

29/65(44.6)

35/64(54.6)

36/72(50.0)

P-value

0.195

0.209

0.469

0.061

0.028

Age at diagnosis

<60

24/91(26.3)

36/89(40.4)

41/88(46.6)

38/83(45.8)

36/91(38.8)

≥60

35/128(27.3)

31/121(29.2)

55/122(45.1)

54/121(44.6)

52/129(38.9)

P-value

0.500

0.017

0.469

0.492

0.512

TNM stage

I

12/20(60.0)

9/20(45.0)

11/20(55.0)

11/20(50.0)

10/21(47.6)

II

18/78(17.2)

24/75(32.0)

31/75(41.3)

28/72(38.9)

32/78(41.0)

III

11/64(17.2)

14/60(23.3)

27/61(44.3)

32/61(52.5)

29/65(44.6)

IV

18/54(33.3)

21/52(40.3)

27/51(52.9)

21/48(43.8)

17/53(32.1)

P-value

0.001

0.160

0.501

0.355

0.481

Tumor depth

T1-T2

16/45(36)

19/46(41.3)

25/45(55.6)

17/42(40.5)

18/47(38.3)

T3-T4

43/173(24.9)

49/163(30.1)

72/164(43.9)

75/161(46.6)

70/172(40.7)

P-value

0.107

0.105

0.111

0.298

0.451

Lymph node status

N0

21/52(40.4)

20/52(38.5)

27/51(52.9)

24/47(51.1)

23/54(42.6)

N1

18/77(23.4)

24/74(32.4)

32/73(43.8)

29/77(37.7)

36/78(46.2)

N3

12/68(17.6)

18/62(29.0)

29/66(43.9)

31/62(50.0)

23/66(34.8)

N4

8/19(42.1)

6/19(31.6)

9/17(52.9)

8/15(53.3)

6/19(31.6)

P-value

0.016

0.760

0.681

0.339

0.452

Distant metastasis

M0

51/190(26.8)

56/183(30.6)

81/182(44.5)

82/179(45.8)

78/192(40.6)

M1

8/28(28.6)

12/26(46.2)

16/27(59.3)

10/24(41.7)

10/27(37.0)

P-value

0.504

0.089

0.110

0.437

0.446

Differentiation

D1

6/12(50.0)

4/11(36.3)

9/12(75.0)

8/12(66.7)

1/13(7.6)

D2

30/78(38.5)

28/76(36.8)

41/74(55.4)

36/71(50.7)

32/79(40.5)

D3

22/123(17.9)

35/120(29.2)

45/120(37.5)

47/116(40.5)

52/125(41.6)

P-value

0.031

0.649

0.006

0.046

0.035