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Fig. 5 | BMC Cancer

Fig. 5

From: Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion

Fig. 5

Antiplatelet agents do not affect the ability of platelets to bind to or to induce EMT-like changes in SK-OV-3 cells. a Platelet adhesion to SK-OV-3 cells in the presence and absence of aspirin or 2MeSAMP was quantified based on the fluorescence detection of CD42b positive platelets (n = 5). b Results are expressed as fold change in mRNA expression in SK-OV-3 cells in the presence of platelets (black bar) and platelets pre-treated with 2MeSAMP (white bar) relative to cells grown in the absence of platelets for 24 h (n = 3). c Results are expressed as fold change in mRNA expression in SK-OV-3 cells in the presence of platelets (black bar) and platelets pre-treated with aspirin (white bar) relative to cells grown in the absence of platelets for 24 h (n = 3). Values are normalised to B2M (beta 2 microglobulin). Data shown are mean value + SD. Student’s t-test was performed to determine significant differences between expression levels of the EMT markers in the SK-OV-3 cells cultured with platelets compared with those cultured with platelets pre-treated with antiplatelet agents. No significant differences were identified (significance was defined as p ≤ 0.05)

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