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Fig. 2 | BMC Cancer

Fig. 2

From: Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

Fig. 2

MRP1 and Notch1IC are induced by NAC in breast cancer patients and their expression is significantly positively associated post-NAC. Immunohistochemistry for either MRP1 or activated Notch1 was performed and quantified on matched pre- and post-NAC breast cancer tissues from 29 patients. a Expression of MRP1 (top) and Notch1IC (bottom) is shown for each individual patient (each black line) both pre- and post-NAC. b Expression of MRP1 and Notch1IC across the cohort as box and whisker plots showing median (line), 25th-75th percentile (box) and min to max values (whiskers). Wilcoxon ranked score, p < 0.0001 for both MRP1 and Notch1IC. c A scatter plot of MRP1 and Notch1IC expression with post-NAC demonstrating a significant positive correlation (rho coefficient 0.5884, p = 0.0008)

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