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Table 5 Potential avoided initial biopsies (IBx), PCa and HGPCa detection and missed rates at IBx using various threshold PCA3 values as a single decision tool

From: Optimizing the clinical utility of PCA3 to diagnose prostate cancer in initial prostate biopsy

Threshold Performed biopsies Avoided biopsies PCa detected PCa delayed HGPCa detected HGPCa delayed
Probability n (%) n (%) n (%) Diagnosis n (%) n (%) Diagnosis n (%)
PCA3 > 17 280 (69,8) 121 (30,2) 96 (86,5) 15 (13,5) 38 (86,4) 6 (13,6)
PCA3 > 21 256 (63,8) 145 (36,2) 93 (83,8) 18 (16,2) 38 (86,4) 6 (13,6)
PCA3 > 24 245 (61,1) 156 (38,9) 90 (81,1) 21 (18,9) 37 (84,1) 7 (15,9)
PCA3 > 25 243 (60,6) 158 (39,4) 89 (80,2) 22 (19,8) 37 (84,1) 7 (15,9)
PCA3 > 35 206 (51,4) 195 (48,6) 78 (70,3) 33 (29,7) 32 (72,7) 12 (27,2)