Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma

Fig. 4

S100A16 over-expression modulated differentiation-related markers in OSCC cell-lines. S100A16 was over-expressed and knocked-down in OSCC-derived cells by retroviral vectors and concomitant modulation of differentiation markers was examined. a Western blot analysis showed up-regulation of several of the differentiation markers with S100A16 over-expression. ** anti human-cytokeratin 13 (sc-58721, Santa Cruz); *anti human-cytokeratin 13 (NCL-CK13, Novacastra). b Up-regulation of cytokeratin 13 in S100A16-CaLH3 was further verified by FACS analysis (b–d). Error bars in (c and d) represent SEM of 3 repeated experiments. Student’s-t test was performed for statistical analysis. d In parallel with over-expression, S100A16 knock-down led to down-regulation of involucrin and cytokeratin 13 in CaLH3 cells

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us