Fig. 4From: Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 statusDose-dependent inhibition of tumor growth in mice that were given oral gavage of vehicle, tamoxifen, or ZB497 at two different doses. Five groups (5 mice/group) of mice bearing MCF-7 xenograft tumors were treated daily with oral gavage of either vehicle (1:10 ethanol/PBS) or a drug at 0.1Â mg/kg or 1Â mg/kg for 21Â daysBack to article page