Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Table 2 Effects of clinically approved natural product antineoplastic agents and of cytochalasin congeners on drug-sensitive and multidrug-resistant human ovarian carcinoma lines

Cell line	SKOV3^a	SKVCR0.015		SKVCR0.1		SKVLB1
IC concentrations (nM) at 96 h	IC₉₀	IC₉₀	RI	IC₉₀	RI	IC₉₀	RI
Doxorubicin	11	125	11	125	11	2900	264
Paclitaxel	2.8	8	3	4	1.4	3900	1400
Vinblastine	1.9	10	5	20	10	3100	1600
Cytochalasin A	1000	1000	1	500	0.5	750	0.75
Cytochalasin B	2250	1500	0.67	1250	0.56	3000	1.33
21, 22-Dihydrocytochalasin B	3000	2400	0.8	1600	0.53	5000	2.5
21, 22-Dihydrocytochalasin B γ-L	40000	30000	0.75	30000	0.75	40000	1
Cytochalasin C	330	250	0.76	125	0.38	8000	24
Cytochalasin D	80	80	1	320	4	8000	100
Cytochalasin E	200	ND		ND		1600	8
Cytochalasin H	100	ND		ND		1600	16
Cytochalasin J	800	ND		ND		3200	4

ISSN: 1471-2407