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Fig. 3 | BMC Cancer

Fig. 3

From: Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Fig. 3

Effects of verapamil and cytochalasins on SK human ovarian carcinoma cell lines. a Effects of verapamil on potentiating SK human ovarian carcinoma sensitivity to cytochalasins B, C, D, and 21,22-dihydrocytochalasin B. Cell lines are arranged in order of increasing drug resistance from left to right. The IC90 concentrations are given in μM. Numbers in black refer to fold sensitization elicited by the addition of 30 μM verapamil. b Effects of cytochalasin A-alone or in combination with 30 μM verapamil against SKVCR0.015 cells. The values are taken as a percentage of 30 μM verapamil-treated cells. c Effects of cytochalasin B-alone or in combination with 30 μM verapamil against SKVCR0.015 cells. The values are taken as a percentage of 30 μM verapamil-treated cells. d Dose response of cytochalasin A-alone or in combination with 30 μM verapamil on the growth of SKVCR0.015 cells. e Dose response of cytochalasin B-alone or in combination with 30 μM verapamil on the growth of SKVCR0.015 cells. For panels d and e, agents were administered for either 48 or 96 h, as indicated in the graphs

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