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Fig. 1 | BMC Cancer

Fig. 1

From: Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

Fig. 1

Effect of 4T1 breast cancer metastases in animals that underwent tumor surgery. Tumor cells were orthotopically implanted in mice mammary fat pads (day 0). Primary tumors were left without surgery or removed by surgical excision, 10 or sixteen (S-16) days later. a Kaplan–Meier plot shows the survival rate of the indicated groups (n = 8). b Additional tumor-bearing or tumor excised mice were sacrificed at 10, 16 or 35 days after 4T1 cells inoculation, lungs were extracted and processed and the number of lung metastases were quantified as described in Methods. 35 (S-16) refers to a group of mice that underwent surgery at day 16 and were checked for lung metastases 19 days later (i.e. 35 days after 4T1 tumor implantation). c Lungs extracted from a healthy control mouse (Control) and from moribund mice showing numerous metastatic nodules (Metastatic lungs). Non-significant (n.s.)

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