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Table 3 Cytokine levels at baseline before and at the beginning of the first clinical symptoms of post-transplant related infections

From: Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

Post-transplant-adverse event Serum level Before post-transplant adverse event Post-transplant adverse event  
   Median Range Median Range P-value
Sepsis IL-6 pg/ml 11.90 2.0 – 73.6 133.00 23.6 – 2856 0.0020
  IL-8 pg/ml 40.0 9.0 – 212.0 650.0 73.4 – 10,385 0.0020
  IL-10 pg/ml 7.20 3.6 – 55.9 16.70 14.3 – 98.8 0.0625
  sIL-2R U/ml 1780.0 973 – 5933 4899.0 1387 – 9680 0.0156
  IL-1 ß ng/ml 0.14 0.1 – 1.99 1.51 0.17 – 3.54 0.0625
  TNF-α pg/ml 5.6 4.0 – 25.7 26.9 6.0 – 204.0 0.0078
Bacteremia IL-6 pg/ml 3.7 2 – 205 13.8 2.5 – 267 <0.0001
  IL-8 pg/ml 21.1 7.5 – 220 35.2 7.70 – 954 0.0006
  IL-10 pg/ml 4.0 1.1 – 26.2 5.5 1.0 – 62.3 0.059
  sIL-2R U/ml 1306.0 296 – 6690 1423 414 – 6689 0.2023
  IL-1 ß ng/ml 0.1 0.1 – 0.35 0.20 0.10 – 1.08 0.0026
  TNF-α pg/ml 8.9 4.0 – 26.4 10.8 4.0 – 456 0.0007
Viremia IL-6 pg/ml 9.2 2.0 – 83.2 11.30 2.0 – 113 0.0008
  IL-8 pg/ml 16.00 6.7 – 67.10 18.40 5.0 – 295 0.1867
  IL-10 pg/ml 4.10 1.0 – 35.9 4.5 1.0 – 134 0.3884
  sIL-2R U/ml 1561.0 461 – 4666 1409 322 – 7284.0 0.7676
  IL-1 ß ng/ml 0.1 0.1 – 0.87 0.2 0.1 – 1.48 0.1755
  TNF-α pg/ml 11.9 4.0 – 127.0 12.2 4.0 – 137.0 0.2909
Fungemia IL-6 pg/ml 5.00 2.0 – 16.0 7.75 2.0 – 267.0 0.1272
  IL-8 pg/ml 23.2 5.0 – 99.9 22.35 5.0 – 243.0 0.5688
  IL-10 pg/ml 3.35 1.6 – 5.1 4.90 2.3 – 39.6 0.4375
  sIL-2R U/ml 1180.0 397 – 2365 1037.0 322 – 3195 0.1289
  IL-1 ß ng/ml 0.1 0.1 – 0.43 0.15 0.1 – 1.01 0.5312
  TNF-α pg/ml 10.9 4.0 – 89.1 9.5 4.0 – 61.1 0.2891
  1. P-value: statistical comparison between baseline measurements and during post-transplant adverse events by the Wilcoxon matched pairs signed rank test