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Fig. 5 | BMC Cancer

Fig. 5

From: Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

Fig. 5

Ras/ERK signal pathway is down-regulated after γ-T3 treatment. As components of SHP2/RAS/ERK pathway, Ras gene expression including H-RAS (a) and K-RAS (b) was decreased as γ-T3 dose increased from 0.5 to 3.0 μg/ml. c ERK protein levels decrease as γ-T3 dose increases. d Western result shows the comparison of p-SHP2 protein level in MCF-7 cells and mammosphere cells (MCF-7-SP). Tub human β-tublin

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