Skip to main content

Table 2 Meta-analysis of the associations between chromosome 6p21 SNPs and NPC susceptibility

From: Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese populations

   

Sample

MAF

   

Heterogeneity

Gene

SNP

Study

Case

Control

Case

Control

P

OR

95 % CI

I2 %

P

HCG9

rs9260734

Tse (2009)

912

1,925

0.22

0.34

6.77E-18

0.54

0.47–0.62

  
  

Bei (2010)

1,583

1,894

0.22

0.33

9.80E-22

0.56

0.49–0.67

  
  

Tang (2012)

923

1,105

-

-

2.63E-11

0.59

0.50–0.69

  
  

Li (2011)

360

360

0.25

0.32

9.70E-03

0.74

0.53–1.01

  
  

Zhao (2012)

535

525

-

0.32

3.30E-07

0.60

0.49–0.73

  
  

Hsu (2012)

336

288

0.24

0.35

1.88E-03

0.57

0.40–0.81

  
  

Guo (2014)

1166

2340

-

-

5.96E-17

0.60

0.53–0.68

  
  

Fixed effect

    

9.68E-57

0.59

0.55–0.63

0

0.7774

  

Random effect

   

9.68E-57

0.59

0.55–0.63

  

HLA-A

rs2517713

Tse (2009)

912

1,925

0.24

0.38

3.90E-20

0.53

0.47–0.61

  
 

rs2860580a

Bei (2010)

5,090

4,957

-

-

3.65E-65

0.58

0.54–0.62

  
  

Tang (2012)

923

1,105

-

-

1.92E-11

0.60

0.52–0.70

  
  

Li (2011)

360

360

0.28

0.36

5.30E-04

0.67

0.48–0.91

  
 

rs9260475a

Zhao (2012)

206

180

-

0.38

1.00E-04

0.49

0.34–0.70

  
  

Hsu (2012)

337

286

0.26

0.38

1.90E-03

0.58

0.41–0.82

  
  

Guo (2014)

1166

2340

-

-

2.44E-16

0.62

0.55–0.70

  
  

Fixed effect

    

1.08E-91

0.58

0.55–0.61

0

0.5265

  

Random effect

   

1.08E-91

0.58

0.55–0.61

  

HLA-F

rs3129055

Tse (2009)

912

1,925

0.41

0.31

7.36E-11

1.51

1.34–1.71

  
  

Bei (2010)

1,583

1,894

0.37

0.30

3.00E-07

1.31

1.19–1.58

  
  

Tang (2012)

923

1,105

-

-

3.43E-02

1.17

1.01–1.34

  
  

Li (2011)

360

360

0.36

0.34

3.69E-01

1.11

0.81–1.50

  
  

Hsu (2012)

344

294

0.38

0.30

4.44E-02

1.42

1.02–1.98

  
  

Guo (2014)

1166

2340

-

-

2.00E-02

1.14

1.02–1.28

  
  

Fixed effect

    

6.44E-12

1.26

1.18–1.34

58

0.0361

  

Random effect

   

1.43E-05

1.28

1.14–1.42

  

GABBR1

rs29232

Tse (2009)

912

1,925

0.59

0.46

8.97E-17

1.67

1.48–1.88

  
  

Bei (2010)

1,583

1,894

0.53

0.43

3.90E-18

1.56

1.43–1.75

  
  

Tang (2012)

923

1,105

-

-

4.35E-06

1.36

1.20–1.56

  
  

Hsu (2012)

342

290

0.53

0.41

2.41E-03

1.63

1.19–2.24

  
  

Guo (2014)

1166

2340

-

-

1.85E-08

1.35

1.21–1.49

  
  

Fixed effect

    

1.46E-30

1.45

1.36–1.54

47

0.1092

  

Random effect

   

1.90E-16

1.47

1.34–1.61

  

GABBR1

rs29230

Tse (2009)

912

1,925

0.18

0.26

4.77E-09

0.64

0.56–0.75

  
  

Bei (2010)

1,583

1,894

0.19

0.27

1.30E-12

0.64

0.54–0.75

  
  

Tang (2012)

923

1,105

-

-

9.48E-09

0.61

0.52–0.72

  
  

Li (2011)

360

360

0.18

0.27

1.43E-04

0.61

0.42–0.86

  
  

Hsu (2012)

341

290

0.17

0.25

2.34E-02

0.63

0.43–0.93

  
  

Guo (2014)

1166

2340

-

-

1.36E-13

0.62

0.57–0.67

  
  

Fixed effect

    

5.78E-34

0.62

0.57–0.67

0

0.9988

  

Random effect

   

5.78E-34

0.62

0.57–0.67

  
  1. aSNPs used as surrogate for rs2517713. The r2 between rs2860580 and rs2517713 was 0.91; r2 between rs2860580 and rs9260475 was 0.90
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us