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Table 2 Meta-analysis of the associations between chromosome 6p21 SNPs and NPC susceptibility

From: Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese populations

    Sample MAF     Heterogeneity
Gene SNP Study Case Control Case Control P OR 95 % CI I2 % P
HCG9 rs9260734 Tse (2009) 912 1,925 0.22 0.34 6.77E-18 0.54 0.47–0.62   
   Bei (2010) 1,583 1,894 0.22 0.33 9.80E-22 0.56 0.49–0.67   
   Tang (2012) 923 1,105 - - 2.63E-11 0.59 0.50–0.69   
   Li (2011) 360 360 0.25 0.32 9.70E-03 0.74 0.53–1.01   
   Zhao (2012) 535 525 - 0.32 3.30E-07 0.60 0.49–0.73   
   Hsu (2012) 336 288 0.24 0.35 1.88E-03 0.57 0.40–0.81   
   Guo (2014) 1166 2340 - - 5.96E-17 0.60 0.53–0.68   
   Fixed effect      9.68E-57 0.59 0.55–0.63 0 0.7774
   Random effect     9.68E-57 0.59 0.55–0.63   
HLA-A rs2517713 Tse (2009) 912 1,925 0.24 0.38 3.90E-20 0.53 0.47–0.61   
  rs2860580a Bei (2010) 5,090 4,957 - - 3.65E-65 0.58 0.54–0.62   
   Tang (2012) 923 1,105 - - 1.92E-11 0.60 0.52–0.70   
   Li (2011) 360 360 0.28 0.36 5.30E-04 0.67 0.48–0.91   
  rs9260475a Zhao (2012) 206 180 - 0.38 1.00E-04 0.49 0.34–0.70   
   Hsu (2012) 337 286 0.26 0.38 1.90E-03 0.58 0.41–0.82   
   Guo (2014) 1166 2340 - - 2.44E-16 0.62 0.55–0.70   
   Fixed effect      1.08E-91 0.58 0.55–0.61 0 0.5265
   Random effect     1.08E-91 0.58 0.55–0.61   
HLA-F rs3129055 Tse (2009) 912 1,925 0.41 0.31 7.36E-11 1.51 1.34–1.71   
   Bei (2010) 1,583 1,894 0.37 0.30 3.00E-07 1.31 1.19–1.58   
   Tang (2012) 923 1,105 - - 3.43E-02 1.17 1.01–1.34   
   Li (2011) 360 360 0.36 0.34 3.69E-01 1.11 0.81–1.50   
   Hsu (2012) 344 294 0.38 0.30 4.44E-02 1.42 1.02–1.98   
   Guo (2014) 1166 2340 - - 2.00E-02 1.14 1.02–1.28   
   Fixed effect      6.44E-12 1.26 1.18–1.34 58 0.0361
   Random effect     1.43E-05 1.28 1.14–1.42   
GABBR1 rs29232 Tse (2009) 912 1,925 0.59 0.46 8.97E-17 1.67 1.48–1.88   
   Bei (2010) 1,583 1,894 0.53 0.43 3.90E-18 1.56 1.43–1.75   
   Tang (2012) 923 1,105 - - 4.35E-06 1.36 1.20–1.56   
   Hsu (2012) 342 290 0.53 0.41 2.41E-03 1.63 1.19–2.24   
   Guo (2014) 1166 2340 - - 1.85E-08 1.35 1.21–1.49   
   Fixed effect      1.46E-30 1.45 1.36–1.54 47 0.1092
   Random effect     1.90E-16 1.47 1.34–1.61   
GABBR1 rs29230 Tse (2009) 912 1,925 0.18 0.26 4.77E-09 0.64 0.56–0.75   
   Bei (2010) 1,583 1,894 0.19 0.27 1.30E-12 0.64 0.54–0.75   
   Tang (2012) 923 1,105 - - 9.48E-09 0.61 0.52–0.72   
   Li (2011) 360 360 0.18 0.27 1.43E-04 0.61 0.42–0.86   
   Hsu (2012) 341 290 0.17 0.25 2.34E-02 0.63 0.43–0.93   
   Guo (2014) 1166 2340 - - 1.36E-13 0.62 0.57–0.67   
   Fixed effect      5.78E-34 0.62 0.57–0.67 0 0.9988
   Random effect     5.78E-34 0.62 0.57–0.67   
  1. aSNPs used as surrogate for rs2517713. The r2 between rs2860580 and rs2517713 was 0.91; r2 between rs2860580 and rs9260475 was 0.90