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Table 2 Toxicity (n = 31)

From: A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

  Number of patients, n (%)
  Grade 1 Grade 2 Grade 3 Grade 4 All grades Grade 3/4
Hematological adverse events
 Anemia 4 4 2 0 10 (32) 2 (6)
 Thrombocytopenia 7 1 0 0 8 (26) 0 (0)
 Neutropenia 4 1 1 0 6 (19) 1 (3)
 Febrile neutropenia 1 0 1 (3) 1 (3)
Non-hematological adverse events
 Stomatitis 7 8 8 0 23 (74) 8 (26)
 Fatigue 13 10 0 23 (74) 0 (0)
 Anorexia 10 9 2 0 21 (68) 2 (6)
 Diarrhea 8 4 3 0 15 (48) 3 (10)
 Skin pigmentation 8 4 0 0 12 (39) 0 (0)
 Hypertension 7 2 1 0 10 (32) 1 (3)
 Nausea 8 1 0 9 (29) 0 (0)
 Epistaxis 9 0 0 0 9 (29) 0 (0)
 Watering eyes 4 1 0 5 (16) 0 (0)
 Vomiting 3 1 0 0 4 (13) 0 (0)
  1. The most common toxicities of all grade were stomatitis (74 %), fatigue (74 %), anorexia (68 %) and diarrhea (48 %)
  2. The major grade 3–4 toxicities were stomatitis (26 %) and diarrhea (10 %)