Fig. 4
From: Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth
BBR suppresses the proliferation of medulloblastoma cells in vitro. a BBR suppressed the proliferation of medulloblastoma cells analyzed by Brdu assay. Medulloblastoma cells were treated with various concentrations of BBR for 36 h. Data are expressed as means ± s.d. from three independent experiments (n = 3). (b-c) BBR suppressed the Gli1 mRNA (b) and ptch1 mRNA (c) expression in medulloblastoma cells. Medulloblastoma cells were exposed to various concentrations of BBR for 24 h, and the cells were collected for RT-qPCR analysis. The results are expressed as mean ± s.d. from three independent experiments (n = 3)