Skip to main content

Advertisement

Table 1 Patient characteristics distributed by AKAP13 status

From: Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Variable AKAP 13 low   AKAP 13 high   P-value
  n % n %  
Total 38   28   
Median age at surgery      
Years (range) 64 (38–85)   61(37–82)   0.211£
WHO type carcinoma      
IDC 33 86.8 23 82.1 0.246*
ILC 4 10.5 4 14.3  
IDC + DCIS 1 2.6 0 0.0  
Unknown 0 0.0 1 3.6  
Tumor diameter      
<= 20 mm 20 52.6 14 50.0 1.000
>20 mm 18 47.4 14 50.0  
Lymph node status      
Negative 29 76.3 14 50.0 0.033
Positive 8 21.1 13 46.4  
Unknown 1 2.6 1 3.6  
Histological grade a      
Grade I 9 23.7 12 42.9 0.374*
Grade II 19 50.0 7 25.0  
Grade III 10 26.3 8 28.6  
Unknown 0 0.0 1 3.6  
Estrogen receptor      
Low (≥10 % < 75 %) 7 18.4 10 35.7 0.160
High (≥75 %) 30 78.9 18 64.3  
Unknown 1 2.6 0 0.0  
Progesterone receptor      
Negative 11 28.9 15 53.6 0.074
Positive 26 68.4 13 46.4  
Unknown 1 2.6 0 0.0  
HER2 status      
Negative 30 78.9 27 96.4 0.366
Positive 4 10.5 1 3.6  
Unknown 4 10.5 0 0.0  
ER305phosporylation      
Negative 25 78.1 18 66.7 0.510
Positive 5 15.6 6 22.2  
Unknown 2 6.3 3 11.1  
  1. P values: patients with unknown values were omitted. P values were calculated using the Fisher’s exact test, except for *Chi square test for trend and £ Mann–Whitney U test
  2. IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, DCIS ductal carcinoma in situ
  3. aAccording to Bloom and Richardson