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Table 1 Patient characteristics distributed by AKAP13 status

From: Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Variable

AKAP 13 low

 

AKAP 13 high

 

P-value

 

n

%

n

%

 

Total

38

 

28

  

Median age at surgery

     

Years (range)

64 (38–85)

 

61(37–82)

 

0.211£

WHO type carcinoma

     

IDC

33

86.8

23

82.1

0.246*

ILC

4

10.5

4

14.3

 

IDC + DCIS

1

2.6

0

0.0

 

Unknown

0

0.0

1

3.6

 

Tumor diameter

     

<= 20 mm

20

52.6

14

50.0

1.000

>20 mm

18

47.4

14

50.0

 

Lymph node status

     

Negative

29

76.3

14

50.0

0.033

Positive

8

21.1

13

46.4

 

Unknown

1

2.6

1

3.6

 

Histological grade a

     

Grade I

9

23.7

12

42.9

0.374*

Grade II

19

50.0

7

25.0

 

Grade III

10

26.3

8

28.6

 

Unknown

0

0.0

1

3.6

 

Estrogen receptor

     

Low (≥10 % < 75 %)

7

18.4

10

35.7

0.160

High (≥75 %)

30

78.9

18

64.3

 

Unknown

1

2.6

0

0.0

 

Progesterone receptor

     

Negative

11

28.9

15

53.6

0.074

Positive

26

68.4

13

46.4

 

Unknown

1

2.6

0

0.0

 

HER2 status

     

Negative

30

78.9

27

96.4

0.366

Positive

4

10.5

1

3.6

 

Unknown

4

10.5

0

0.0

 

ER305phosporylation

     

Negative

25

78.1

18

66.7

0.510

Positive

5

15.6

6

22.2

 

Unknown

2

6.3

3

11.1

 
  1. P values: patients with unknown values were omitted. P values were calculated using the Fisher’s exact test, except for *Chi square test for trend and £ Mann–Whitney U test
  2. IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, DCIS ductal carcinoma in situ
  3. aAccording to Bloom and Richardson