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Table 2 Genetic and epigenetic alterations in the primary tumor and matched metastases

From: Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses

Tumor sample Gene hypermethylationa MSIb status BRAF KRAS NRAS PIK3CA
Primary rectal cancer APC; CDH13; WT1 MSS - - - -
Hepatic metastasis APC; CDH13 MSS - - - -
Lung metastasis APC; CDH13; WT1; DAPK1; CHFR; GATA5 MSS - - - -
Lymph nodal metastasis APC; CDH13; PAX5; DAPK1; CHFR; GATA5 MSS - - - -
  1. aList of hypermethylated genes; clonal gene hypermethylations are shown in bold font. APC adenomatous polyposis coli, CDH13 cadherin 13
  2. bMSI microsatellite instability. MSS: microsatellite stable. -: absence of BRAF, KRAS, NRAS, PIK3CA mutations assayed using the myriapod colon status panel