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Table 2 Genetic and epigenetic alterations in the primary tumor and matched metastases

From: Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses

Tumor sample

Gene hypermethylationa

MSIb status

BRAF

KRAS

NRAS

PIK3CA

Primary rectal cancer

APC; CDH13; WT1

MSS

-

-

-

-

Hepatic metastasis

APC; CDH13

MSS

-

-

-

-

Lung metastasis

APC; CDH13; WT1; DAPK1; CHFR; GATA5

MSS

-

-

-

-

Lymph nodal metastasis

APC; CDH13; PAX5; DAPK1; CHFR; GATA5

MSS

-

-

-

-

  1. aList of hypermethylated genes; clonal gene hypermethylations are shown in bold font. APC adenomatous polyposis coli, CDH13 cadherin 13
  2. bMSI microsatellite instability. MSS: microsatellite stable. -: absence of BRAF, KRAS, NRAS, PIK3CA mutations assayed using the myriapod colon status panel
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BMC Cancer

ISSN: 1471-2407

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