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Fig. 2 | BMC Cancer

Fig. 2

From: Adenosine A2b receptor promotes progression of human oral cancer

Fig. 2

Evaluation of ADORA2B protein expression in primary OSCCs. a, b Representative IHC results of ADORA2B in normal oral tissue and primary OSCC. a Normal oral tissues show almost negative immunostaining. Original magnification, ×100. Scale bars, 50 mm. b ADORA2B-positive cases of OSCC. Positive immunoreaction for ADORA2B is detected in the cytoplasm. Original magnification, ×400. Scale bars, 10 mm. c The status of ADORA2B protein expression in primary OSCCs (n = 100) and the normal counterparts based on an IHC scoring system. IHC scores are calculated as follows: IHC score = 1 × (number of weakly stained cells in the field) + 2 × (number of moderately stained cells in the field) + 3 × (number of intensely stained cells in the field). The ADORA2B IHC scores for normal oral tissues and OSCCs range from 20 to 110 (median, 51) and 99 to 245 (median, 139.5), respectively. ADORA2B protein expression levels in OSCCs are significantly (p < 0.05, Mann–Whitney U test) higher than in normal oral tissues. d Kaplan–Meier survival curve for overall survival rates of patients with OSCCs based on the levels of ADORA2B expression. Up-regulated ADORA2B expression was not significantly related to overall survival rates (N.S. = p = 0.8037). The log-rank statistic was used to test the difference in survival times between the groups. ADORA2B (+), up-regulated ADORA2B; ADORA2B (−), down-regulated ADORA2B

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