Fig. 3

The comparison between plasma steady-state concentration of (Z)-endoxifen level and corresponding metabolic ratio. The metabolic ratio (MR) was estimated as (Z)-endoxifen plasma concentration divided by the sum of concentrations of the remaining measured compounds. The MR value of 0.0146 was delineated as the correlation coefficient with the level of 6 ng/ml. The assigned CYP2D6 functional category, based on CYP2D6 genotype, is indicated in color