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Table 3 Relationship between LC3B staining patterns and histopathological parameters in Group 1 (neoadjuvant-naïve) esophageal adenocarcinoma patients. Statistical analysis was carried out using chi-squared test (* p < 0. 05)

From: LC3B globular structures correlate with survival in esophageal adenocarcinoma

 LC3B CytoplasmicLC3B Globular structures
 NegativePositivep–valueNegativePositivep–value
Differentiation
 Well3(5.1 %)8(17.8 %)0.015*8(14.5 %)3(6.1 %)0.292
 Moderate29(49.2 %)27(60.0 %)30(54.5 %)26(53.1 %)
 Poor27(45.8 %)10(22.2 %)17(30.9 %)20(40.8 %)
Tumor staging
 Stage I8(13.6 %)9(20.0 %)0.001*12(21.8 %)5(10.2 %)0.003*
 Stage II9(15.3 %)20(44.4 %)21(38.2 %)8(16.3 %)
 Stage III-IV42(71.2 %)16(35.6 %)22(40.0 %)36(73.5 %)
Lymphatic mets
 Negative11(18.6 %)23(51.1 %)0.001*24(43.6 %)10(20.4 %)0.013*
 Positive48(81.4 %)22(48.9 %)31(56.4 %)39(79.6 %)
Vascular invasion
 Negative34(57.6 %)29(64.4 %)0.54636(65.5 %)27(55.1 %)0.319
 Positive25(42.4 %)16(35.6 %)19(34.5 %)22(44.9 %)
Neural invasion
 Negative36(61.0 %)39(86.7 %)0.004*41(74.5 %)34(69.4 %)0.558
 Positive23(39.0 %)6(13.3 %)14(25.5 %)15(30.6 %)