Fig. 2From: A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous womenDistribution of major SNP sites in FATS locus and validation of rs11245007. a The illustration of genomic organization of human FATS locus. b The distribution of SNP sites in FATS exons. MAF: minor allele frequency. c Validation of rs11245007 genotypes in Chinese population. d Sequence alignment of amino acid residues within RING/HECT hybrid domain between human FATS and mouse FATS. The conserved catalytic Cys residue of FATS as a unique E2-independent E3 is highlightedBack to article page