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Table 3 Survival analysis of immunohistochemical scores after cut point analysis

From: Prognostic significance of multiple kallikreins in high-grade astrocytoma

    Univariable Analysis Multivariable Analysis
  N Median Survival Hazard Ratio 95 % CI P a Hazard Ratio 95 % CI P a
KLK6 % 60 355 1.63 1.06–2.50 0.027 1.35 0.87–2.10 0.18b
       1.55 1.10–2.40 0.052c
<3 32 419       
≥3 28 320 2.07 1.14–3.76 0.017 1.36 0.72–2.57 0.34b
       1.93 1.03–3.63 0.04c
KLK6-IR 60 355 1.16 1.02–1.31 0.020 1.10 0.96–1.25 0.17b
       1.15 1.01–1.30 0.03c
<10 48 408       
≥10 12 276 2.36 1.19–4.68 0.014 1.72 0.84–3.54 0.14b
       2.4 1.20–4.78 0.01c
KLK7-IR 60 355 1.17 1.02–1.34 0.025 1.10 0.95–1.28 0.20b
       1.15 1.00–1.32 0.057c
<9 38 422       
≥9 22 294 2.15 1.20–3.87 0.010 1.47 0.77–2.80 0.24b
       2.04 1.10–3.77 0.024c
KLK9 % 60 355 2.25 1.21–4.22 0.011 1.68 0.86–3.3 0.13b
       2.13 1.12–4.05 0.021c
<4 29 422       
=4 31 311 1.70 0.98–2.95 0.061 1.42 0.79–2.57 0.24b
       1.58 0.89–2.79 0.12c
  1. Cox proportional hazards regression analysis assessing the association of kallikrein protein expression with patient survival in 60 grade IV astrocytoma specimens
  2. aProportional hazards regression
  3. bAdjusted for age, gender and performance score
  4. cAdjusted for gender and performance score