Fig. 2From: Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4Effect of miR-10b levels on response to tamoxifen. a Ectopic over-expression of miR-10b in MCF-7 and T47D cells, through transfections with pre-miR-10b oligonucleotides, increased tamoxifen resistance, (b) silencing of miR-10b in MCF7TR cells, through transfections with anti-miR-10b oligonucleotides, decreased their tamoxifen resistance and (c) ectopic over-expression of miR-10b in MCF-7 and T47D cells significantly attenuated tamoxifen-induced inhibition of migration potential. Cells were treated with indicated doses of tamoxifen for 48 h. *p < 0.05, **p < 0.01Back to article page