Fig. 9From: Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activationProposed mechanism of action of MFX and CFX induced S-phase arrest and apoptosis. MFX and CFX causes S-phase arrest by decreasing the levels of Cyclin-A, Cyclin-E, CDK2, p21 and p27 in both the cell lines. Both FQs also leads to activation of extrinsic pathway of apoptosis via caspase-8 and ERK1/2 which then disrupts mitochondrial membrane potential via activation of Bid and proapoptotic Bak, as well as downregulates Bax and antiapoptotic protein Bcl-xL, which finally promotes activation of caspase-9,3 and leads to apoptosis. Furthermore MFX and CFX also suppresses cell survival pathway by downregulating the levels of pAKT and cMYCBack to article page