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Fig. 3 | BMC Cancer

Fig. 3

From: Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation

Fig. 3

MFX and CFX induced apoptosis is caspase-8 dependent in both the cell lines. a MFX and CFX induced Caspase-8 activity in a time dependent manner in MIA Paca-2 (i), and Panc-1 cells (ii). Here vertical axis represents fold change in caspase activity and horizontal axis represents time in hours. *p < 0.015, #p < 0.05 b Caspase-8, 9, 3 activity under the effect of MFX and CFX in presence or absence of caspase-8 inhibitor in MIA PaCa-2 (i), and Panc-1 (ii) cells. *p < 0.015, #p < 0.05 versus MFX/CFX. c Abolishment of apoptosis in MIA PaCa-2 (i), and Panc-1 (ii), cells in presence of caspase-8 inhibitor as assessed by annexin-V assay. Cell death is represented in form of bar graph where vertical axis represents % apoptotic cells and horizontal axis represents presence or absence of caspase-8 inhibitor (μM) along with MFX and CFX concentration in μg/ml. Bar graph represents mean ± SEM from three independent experiments. *p < 0.015, #p < 0.05 versus MFX/CFX

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