Fig. 1From: CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic featuresBajoran Purple (BJP) chromogen was used to mark CD147 expression in prostate samples. BJP was separated from the hematoxylin (HT) counterstain using inForm software (a-f) and was then quantified in the plasma membrane (g). No significant differences were observed between benign prostatic tissue (BPT; n = 46 patients) and benign prostatic hyperplasia (BPH; n = 23) samples (p = 0.15) or high-grade intraepithelial neoplasia (HGPIN; n = 24; p = 0.63). Significant decreases in expression were observed in localized prostate cancer (PCa local; n = 42; p = 0.02), aggressive prostate cancer (PCa aggr.; n = 31; p = 0.004), and metastases (Mets; n = 20; p = 0.001) compared to BPT. E-cadherin was quantified for validation of membrane segmentation (h), and significant decreases in expression were found in all PCa samples (p < 0.0001) compared to BPT but not in BPH or HGPIN (p > 0.05) *p < 0.05Back to article page