Table 3 Associations between SENP1 immunohistochemistry results and cell proliferation as measured by Ki67 immunohistochemistry in all cancers and subsets of cancers defined by Gleason grade, and the ERG/PTEN status. Ki67LIav = average Ki67 labeling index. * P-value for SENP1 negative vs. positive (combined groups of weak, moderate, strong)
| Â | Â | SENP1 IHC | Number | Ki67LI av | P | |
|---|---|---|---|---|---|---|
All cancers |  | negative | 3,880 | 2.58 | ±0.04 |  |
|  | weak | 679 | 3.05 | ±0.10 | <0.0001 | |
|  | moderate | 838 | 3.31 | ±0.09 | * < 0.0001 | |
|  | strong | 419 | 3.21 | ±0.13 |  | |
Gleason | ≤3 + 3 | negative | 980 | 2.07 | ±0.07 |  |
weak | 112 | 2.30 | ±0.19 | <0.0001 | ||
moderate | 137 | 2.55 | ±0.18 | * < 0.0001 | ||
strong | 75 | 2.65 | ±0.24 |  | ||
3 + 4 | negative | 2,238 | 2.51 | ±0.05 |  | |
weak | 396 | 3.02 | ±0.12 | <0.0001 | ||
moderate | 520 | 3.14 | ±0.10 | * < 0.0001 | ||
strong | 252 | 3.24 | ±0.15 |  | ||
4 + 3 | negative | 504 | 3.34 | ±0.16 |  | |
weak | 119 | 3.69 | ±0.32 | 0.4329 | ||
moderate | 137 | 3.85 | ±0.30 | *0.1209 | ||
strong | 71 | 3.56 | ±0.42 |  | ||
≥4 + 4 | negative | 133 | 4.74 | ±0.39 |  | |
weak | 51 | 3.41 | ±0.63 | 0.0516 | ||
moderate | 41 | 5.90 | ±0.70 | *0.5643 | ||
strong | 18 | 3.78 | ±1.06 |  | ||
ERG-positive cancers without PTEN deletion |  | negative | 814 | 2.92 | ±0.09 |  |
|  | weak | 151 | 3.44 | ±0.21 | 0.0315 | |
|  | moderate | 196 | 2.99 | ±0.19 | *0.0293 | |
|  | strong | 80 | 3.59 | ±0.29 |  | |