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Table 4 Kaplan-Meier median progression-free survival (PFS) and overall survival (OS) estimates for patients with and without early tumor shrinkage

From: Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer

  

Early tumor shrinkage at 6 weeks

p-value

<10 %

≥10 %

GEMOX

PFS (months) median (95 % CI)

2.5 (1.7-3.2)

5.4 (2.0-8.9)

0.03

GEMOX plus erlotinib

PFS (months) median (95 % CI)

1.3 (1.0-1.6)

8.3 (5.7-11.0)

0.00

Overall

PFS (months) median (95 % CI)

2.1 (0.9-3.3)

7.3 (5.6-8.9)

0.00

  

Early tumor shrinkage at 6 weeks

p-value

<10 %

≥10 %

GEMOX

OS (months) median (95 % CI)

4.8 (1.6-7.9)

9.5 (7.5-11.4)

0.03

GEMOX plus erlotinib

OS (months) median (95 % CI)

6.4 (3.1-9.6)

11.4 (7.6-15.2)

0.00

Overall

OS (months) median (95 % CI)

5.8 (3.0-8.5)

10.7 (8.9-12.6)

0.00