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Table 4 SLUG expression in tumor cells and tumor stroma

From: Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer

Variable

 

SLUG expression in breast tumor cellsa

SLUG expression in tumor stromaa

N

Mean

SEM

p-value b

Mean

SEM

p-value b

All

102

54.4

5.1

NA

37.3

2.8

NA

T-stage

       

 1

64

56.7

6.5

0.42

41.3

3.5

0.08

 >1

38

50.5

8.3

 

30.8

4.5

 

N-stage

       

 0

60

61.3

6.6

0.10

38.0

3.7

0.67

 >1

42

44.4

7.9

 

36.3

4.4

 

Grade

       

 1 and 2

60

62.3

6.4

0.007

38.6

3.7

0.58

 3

40

39.5

7.7

 

35.0

4.5

 

Histology

       

 IDC

85

51.3

5.5

0.18

38.9

3.1

0.28

 Other

17

70.6

12.7

 

28.8

7.0

 

Hormone receptor status

       

 Negative

16

53.8

12.8

0.78

31.9

7.1

0.32

 Positive

86

54.5

5.6

 

38.4

3.1

 

HER2 status

       

 Negative

16

45.3

12.8

0.29

39.4

7.1

0.46

 Positive

86

56.1

5.6

 

36.9

3.1

 

Ki 67 (cut-off 14 %)

       

 Low

51

68.2

6.9

0.002

32.9

3.9

0.09

 High

51

39.9

7.0

 

41.8

4.0

 

Epithelial CTC

       

 Present

12

55.8

14.8

0.81

45.8

8.1

0.41

 Absent

90

54.2

5.5

 

36.2

3.0

 

EMT CTC

       

 Present

16

52.5

12.8

0.97

31.3

7.1

0.29

 Absent

86

54.7

5.6

 

38.5

3.1

 

Any CTC

       

 Present

25

55.2

10.2

0.78

37.2

5.7

0.88

 Absent

77

54.1

5.9

 

37.4

3.3

 
  1. aProtein expression evaluated semi quantitatively by immunohistochemistry
  2. bNonparametric Mann–Whitney U test