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Table 4 Univariate proportional-hazards regression analysis of cofactors on overall survival in glioblastoma patients

From: Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

Cofactors

HR

95 % CI

P value

Study group

Age <60 years

1.18

0.62–2.25

0.62

Karnofsky Performance Status >70

1.00

0.35–2.84

0.99

Resection

0.81

0.44–1.54

0.72

Gross Total Resection

1.09

0.56–2.12

0.81

Study medication

0.95

0.48–1.87

0.88

MGMT promoter methylation

0.63

0.31–1.27

0.19

Reference group

Age <60 years

0.78

0.27–2.61

0.73

Karnofsky Performance Status >70

n.e.

n.e.

n.e.

Resection

0.81

0.35–1.85

0.61

Gross Total Resection

0.75

0.50–1.12

0.16

MGMT promoter methylation

0.43

0.18–0.99

0.048

  1. Abbreviations: CI = Confidence interval; HR = Hazard ratio; SVZ = Subventricular zone; MGMT = O6-methylguanine-DNA methyltransferase