Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

Fig. 3

IC50 curves. CMT-U27 (high TOP/FOP ratio, >30) and CIPm cells (low TOP/FOP ratio, <2) were grown for 40 h with the three inhibitors, BEZ235 (a), Everolimus (b) and Src-l1 (c) in increasing concentrations (BEZ235 0.1nM–100 uM, Everolimus 0.01 nM–10 μM and Src-I1 0.1 μM–20 μM). After 40 h the cell viability was measured with a MTT assay. Results, expressed as % of control, are the mean (±SEM) of three independent experiments. *P < 0.01 versus appropriate cell line control (DMSO). IC50 values were calculated with Sigma-Plot software (version 12.5)

Back to article page