Fig. 1

Establishment of acquired resistance to 17-DMAG in H3122 and H2228 cells. Cell viability and the drug concentrations responsible for 50 % growth inhibition were determined using the MTT assay. Cells were treated with 17-DMAG, AUY922, crizotinib, or TAE-684 for 72 h. The values were calculated with data from at least three independent experiments. Bars represent standard deviation. Resistant cells to 17-DMAG were still sensitive to AUY922 and ALK tyrosine kinase inhibitors such as crizotinib and TAE-684