Fig. 3
From: A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model
a Measured decreases in perfusion rates (ml/100 g x min) in untreated, TMZ- or AG119-treated GL261 mouse gliomas. Perfusion rates were measured using an arterial spin label perfusion MRI method, and relative decreases in tumors were obtained compared to the contralateral side. There were significant increases in tumor perfusion rates in both AG119 and TMZ-treated tumors (*p < 0.05), compared to untreated tumors, which had substantially decreased perfusion rates. b-d Perfusion MR images of untreated (b), TMZ (c), and AG119-treated (d) GL261 glioma-bearing mice. T2-weighted morphological images are in the top panels (i), and perfusion maps are in the bottom panels (ii). Dark region in panel Bii depicts decreased perfusion rates in an untreated tumor, which is not as severe in treated tumors (panels cii and dii). Tumors are outlined in red