Skip to main content

Table 3 Distribution of the STAT3 rs744166 genotypes according to the gender, mean age, CagA status and EPIYA-C patterns in patients with gastritis and gastric cancer

From: STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Disease

STAT3 genotypes

AA

AG

GG

Total

n (%)

n (%)

n (%)

n (%)

Gastritis (n = 275)

  Female

61 (33.7)

78 (43.1)

42 (23.2)

181 (65.8)

  Male

27 (28.7)

36 (38.3)

31 (33.0)

94 (34.2)

  Mean age in yrs (SD)

49.6 (17.1)

53.9 (18.6)

58.6 (15.3)

53.8 (17.6)

  cagA -ve

26 (25.7)

49 (48.5)

26 (25.7)

101 (36.7)

  cagA +ve

62 (35.6)

65 (37.4)

47 (27.0)

174 (62.3)

  EPIYA-AB

1 (25.5)

1 (25.5)

2 (50.0)

4 (2.3)

  EPIYA-ABC

44(32.1)

53 (38.7)

40 (29.2)

137 (78.7)

  EPIYA-ABCC

15 (53.6)

8 (28.6)

5 (17.8)

28 (16.1)

  EPIYA-ABCCC

2 (40.0)

3 (60.0)

0

5 (2.9)

Gastric cancer (n = 232)

  Female

19 (21.8)

41 (47.1)

27 (31.0)

87 (37.5)

  Male

40 (27.6)

61 (42.1)

44 (30.3)

145 (62.5)

  Mean age in yrs (SD)

63.4 (13.3)

61.5 (12.9)

61.7 (13.6)

62.0 (13.2)

  cagA -ve

2 (10.5)

11 (57.9)

6 (31.6)

19 (8.2)

  cagA +ve

57 (26.8)

91 (42.7)

65 (30.5)

213 (91.8)

  EPIYA- AB

0

2 (66.7)

1 (33.3)

3 (1.4)

  EPIYA-ABC

28 (23.1)

53 (43.8)

40 (33.1)

121 (56.8)

  EPIYA-ABCC

22 (30.1)

30 (41.1)

21 (28.8)

73 (34.3)

  EPIYA-ABCCC

7 (43.8)

6 (37.5)

3 (18.7)

16 (7.5)

  1. n, number; SD, standard deviation; yrs, years. -ve, negative; +ve, positive