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Table 3 Distribution of the STAT3 rs744166 genotypes according to the gender, mean age, CagA status and EPIYA-C patterns in patients with gastritis and gastric cancer

From: STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Disease STAT3 genotypes
AA AG GG Total
n (%) n (%) n (%) n (%)
Gastritis (n = 275)
  Female 61 (33.7) 78 (43.1) 42 (23.2) 181 (65.8)
  Male 27 (28.7) 36 (38.3) 31 (33.0) 94 (34.2)
  Mean age in yrs (SD) 49.6 (17.1) 53.9 (18.6) 58.6 (15.3) 53.8 (17.6)
  cagA -ve 26 (25.7) 49 (48.5) 26 (25.7) 101 (36.7)
  cagA +ve 62 (35.6) 65 (37.4) 47 (27.0) 174 (62.3)
  EPIYA-AB 1 (25.5) 1 (25.5) 2 (50.0) 4 (2.3)
  EPIYA-ABC 44(32.1) 53 (38.7) 40 (29.2) 137 (78.7)
  EPIYA-ABCC 15 (53.6) 8 (28.6) 5 (17.8) 28 (16.1)
  EPIYA-ABCCC 2 (40.0) 3 (60.0) 0 5 (2.9)
Gastric cancer (n = 232)
  Female 19 (21.8) 41 (47.1) 27 (31.0) 87 (37.5)
  Male 40 (27.6) 61 (42.1) 44 (30.3) 145 (62.5)
  Mean age in yrs (SD) 63.4 (13.3) 61.5 (12.9) 61.7 (13.6) 62.0 (13.2)
  cagA -ve 2 (10.5) 11 (57.9) 6 (31.6) 19 (8.2)
  cagA +ve 57 (26.8) 91 (42.7) 65 (30.5) 213 (91.8)
  EPIYA- AB 0 2 (66.7) 1 (33.3) 3 (1.4)
  EPIYA-ABC 28 (23.1) 53 (43.8) 40 (33.1) 121 (56.8)
  EPIYA-ABCC 22 (30.1) 30 (41.1) 21 (28.8) 73 (34.3)
  EPIYA-ABCCC 7 (43.8) 6 (37.5) 3 (18.7) 16 (7.5)
  1. n, number; SD, standard deviation; yrs, years. -ve, negative; +ve, positive