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Table 3 Results related to anti-genotoxicity tests of AMS049 through the comet assay in peripheral blood cells

From: A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

Experimental groups

Damaged cells

Damage classes

Score

%DR

0

1

2

3

Group 1

22.80 ± 5.04a

77.40 ± 5.07

20.00 ± 4.86

2.80 ± 0.80

0.00 ± 0.00

25.60 ± 5.34a,b

-

Group 2

86.40 ± 3.15c

13.20 ± 3.38

64.00 ± 2.02

17.20 ± 1.88

5.20 ± 1.39

114.00 ± 7.45c

-

Group 3

30.80 ± 4.39a,b

69.20 ± 4.40

28.40 ± 3.96

2.40 ± 0.75

0.00 ± 0.00

33.20 ± 4.91a,b

-

Group 4

48.80 ± 8.89b

51.20 ± 8.90

36.00 ± 4.61

12.40 ± 4.57

0.40 ± 0.40

62.00 ± 13.98b

-

Group 5

65.40 ± 3.01b,c

34.60 ± 3.01

47.20 ± 2.59

13.80 ± 1.98

4.40 ± 1.57

88.00 ± 5.26b,c

33.02

Group 6

65.20 ± 5.81b,c

34.80 ± 5.81

50.20 ± 3.95

11.20 ± 3.93

3.80 ± 2.33

84.00 ± 13.52b.c

33.33

Group 7

NA

NA

NA

NA

NA

NA

NA

  1. SE: Standard error
  2. NA: Not analysed
  3. %DR: Percentage of damage reduction
  4. Different letters indicate statistically significant differences (p < 0.05; ANOVA/Tukey)