Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value

Table 5 Univariable and multivariable analyses of prognostic factors for 15-year breast cancer specific survival in 309 cases of early, invasive breast cancer

Prognostic factor	Univariable Cox regression analysis			Multivariable Cox regression analysis
	HR	95 % CI	p-value	HR	95 % CI	p-value
Ki67: low	0.55	0.34−0.89	0.014	1.38	0.56−3.38	0.485
MCM2: low	0.27	0.12−0.59	0.0004	0.352	0.07−1.85	0.218
Geminin: low	0.51	0.31−0.84	0.007	0.824	0.34−2.02	0.673
Histological grade: 3	1.95	1.41−2.69	<0.0001	1.42	0.68−2.96	0.346
ER status: positive	0.32	0.2−0.5	<0.0001	0.737	0.32−1.72	0.48
HER2 status: positive	1.65	0.84−3.25	0.143	0.545	0.2−1.5	0.241
LN status: positive	3.35	1.98−5.66	<0.0001	3.44	1.54−7.72	0.002
Age > 50 year	0.85	0.53−1.34	0.477	1.36	0.63−2.91	0.431
Tumour size: medium	0.76	0.23−2.49	0.891	1.38	0.16−12	0.772
Tumour size: small	0.8	0.25−2.6	0.891	2.84	0.32−25.35	0.35
After backward stepwise regression
Grade: 3	1.84	1−3.38	0.0502
LN status: positive	3.9	1.79−8.5	0.0006

ISSN: 1471-2407