Fig. 2

Univariable breast cancer-specific analyses among 309 invasive breast carcinomas. Kaplan Meier curves showing breast cancer-specific survival (BCSS) in relation to high (solid line) and low (dotted line) expression of Ki67 (a), MCM2 (c) and Geminin (e). The cut-offs of percentage expression were 8, 12 and 2.33 for Ki67, MCM2 and Geminin, respectively. Log rank p-values are stated. The number of patients at risk for every 2.5 years is given for each subgroup. Using time-dependent Receiver Operating Characteristic (ROC) curves for 15-year BCSS, optimal cut-offs were calculated for Ki67 (b), MCM2 (d) and Geminin (f)