Skip to main content

Table 4 Detailed bioinformatic characteristics of TMEMs with topology and function predictions. 1 - Metaserver prediction. 2 - Localizome prediction, 3 - PSORT II prediction. 4 - Functional data available; protein localized in Golgi apparatus, endosomes and lysosomes. GI - GenInfo Identifier. TM - transmembrane helix segment. ER - endoplasmic reticulum. Mit – mitochondrial. Nuc – nuclear. Cyt – cytoplasmic. n/a - no result

From: Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

Property TMEM213 TMEM207 TMEM61 TMEM45B TMEM30B RTP3 TMEM72 TMEM116 SLC35G2 TMEM45A
Full name transmembrane protein 213 precursor transmembrane protein 207 precursor transmembrane protein 61 transmembrane protein 45B transmembrane protein 30B receptor-transporting protein 3 transmembrane protein 72 transmembrane protein 116 isoform 1 solute carrier family 35 member G2 transmembrane protein 45A
Alternative names UNQ846 CDC50B LTM1; TMEM7 KSP37; C10orf127; bA285G1.3 TMEM22 DERP7
NP (NCBI) 001078898.1 997199.1 872338.1 620143.1 001017970.1 113628.1 001116848.1 001180460.1 079522.2 060474.1
GI 146229352 46409276 32698902 20270331 63003930 13899263 183227675 302058299 148224156 8922243
Protein isoforms 1 1 1 1 1 1 1 3 1 1
Transcript variants 1 1 1 1 1 1 1 3 3 1
Human length (aa) 107 146 210 275 351 232 275 337 412 275
Pfam TMEM213 family in eukaryotes; 154 aa; unknown function n/a TMEM61 family in eukaryotes; 150–211 aa; unknown function DUF716 family in metazoa (unknown function) and plants (response to viral attack) CDC50/ LEM3 (ligand-effect modulator 3) family in glucocorticoid receptor pathway zf-3CxxC family with zinc-binding domain n/a n/a EamA drug/metabolite transporter-like family with two copies of EamA domain DUF716 family in metazoa (unknown function) and plants (response to viral attack)
Tertiary structure prediction1 n/a Similar to TM protein stannin (PDB Id: 1zza) n/a n/a n/a Similar to Zn-binding proteins (PDB Id: 2cup; 2dkt; 2e2z; 3hcs) n/a Similar to human adrenoreceptor (PDB Id: 2rh1; 2r4r) and human adenoreceptor (PDB Id: 3eml) Similar to TM domain of the multidrug-resistance antiporter from E. coli EmrE (PDB Id: 3b5d) n/a
TM domains 2 1 1 2 1 1 2 2 2 7 7 7 2 2 2 1 1 1 3 4 1 6 6 3 10 10 8 7 7 5
1 2 3
Predicted topology3 Type 1a with cyt tail (92 to 107) Type 1a with cyt tail (71 to 146) Type 3a Type 3b Type 3a Type Nt with cyt tail (1 to 211) Type 2 with cyt tail (1 to 94) Type 3a Type 3a Type 3a
Cleavable N-terminal signal peptide3 Yes (1 to 27) Yes (1 to 29) No No No No No Yes (1 to 50) No No
Cytoplasmic/ Nuclear discrimination3 Nuc (55.5) Cyt (94.1) Nuc (70.6) Cyt (94.1) Cyt (89) Cyt (89) Cyt (94.1) Cyt (94.1) Cyt (94.1) Cyt (94.1)
Subcellular localization3 ER (44.4 %) ER (44.4 %) Mit (39.1 %) Nuc (34.8 %) ER (66.7 %) ER (39.1 %) Mit (39.1 %) Cyt (30.4 %) Mit (30.4 %) ER (43.5 %) ER4 (55.6 %) ER (77.8 %)