Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies

Table 3 OR values for NSCLC subgroups according to clinical characteristics

Outcome of interest	Studies	Patients	OR	95%CI	P value	Model	H, I², P value
Age (>60 vs. <60)	n = 6	1531	1.08	0.85-1.37	0.553	Fixed	5.37,6.9 %,0.37
Gender (Male vs. Female)	n = 11	2696	1.89	1.53-2.33	0.000	Fixed	10.52,5.0 %,0.40
Asian	n = 8	1933	2.18	1.67-2.81	0.000	Fixed	5.97,0.0 %,0.54
Non-Asian	n = 3	763	1.38	0.96-1.99	0.084	Fixed	0.97,0.0 %,0.61
Smoke habits (Smoke vs. Non-smoke)	n = 7	1785	2.20	1.72-2.82	0.000	Fixed	4.77,0.0 %,0.57
Non-ADC vs. ADC	n = 15	3185	1.88	1.60-2.22	0.000	Fixed	17.13,18.3 %,0.25
Asian	n = 10	2345	2.22	1.82-2.70	0.000	Fixed	3.81,0.0 %,0.92
Non-Asian	n = 5	840	1.31	0.98-1.75	0.073	Fixed	4.74,15.6 %,0.32
T _2-4 vs T ₁	n = 9	2156	1.46	1.13-1.88	0.004	Fixed	3.13,0.0 %,0.93
Asian	n = 7	1938	1.47	1.12-1.94	0.006	Fixed	2.86,0.0 %,0.83
Non-Asian	n = 2	218	1.37	0.71-2.65	0.349	Fixed	0.23,0.0 %,0.63
N _1-3 vs N ₀	n = 11	2443	1.01	0.83-1.22	0.927	Fixed	10.73,6.8 %,0.38
Differentiation (well vs. moderate/poor)	n = 9	2029	1.47	1.15-1.88	0.002	Fixed	6.04,0.0 %,0.64
Asian	n = 7	1837	1.50	1.15-1.94	0.002	Fixed	5.14,0.0 %,0.53
Non-Asian	n = 2	192	1.28	0.60-2.74	0.517	Fixed	0.81,0.0 %,0.37

Abbreviation: ADC adenocarcinoma, CI confidence interval, Fixed, Fixed, Inverse Variance model, H Heterogeneity, I² I-squared, OR,odds Ratio

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