Table 4 SRS for BM from MM: overview of recent literature
From: Linear accelerator-based stereotactic radiosurgery in 140 brain metastases from malignant melanoma
Lwu 2013 | Marcus 2013 | Bernard 2012 | Liew 2011 | Present study | |
|---|---|---|---|---|---|
Number of patients | 36 (20 melanoma) | 135 | 54 | 333 | 84 |
SRS technique | Gamma Knife | SRS | Cyber Knife | Gamma Knife | Linac based SRS |
Median dose | 21 Gy | n. r. | 24 Gy/80 % isodose | 18 Gy marginal dose | 20 Gy/80 % isodose |
Follow-up [months] | 6 | n. r. | 5 | 3.8 | 7 |
Count of BM [n] | 1: 15 | 1: 80 | Median 1 (1–6) | 1: 122 | 1: 49 |
2–3: 35 | 2–3: 104 | 2–3: 31 | |||
≥2: 21 | ≥4: 20 | ≥4: 107 | ≥4: 4 | ||
Response to SRS [%] | |||||
Remission | 29 | 42 | |||
Stable | n. r. | n. r. | n. r. | 61 | 39 |
Progression | 10 | 17 | |||
Median survival after SRS | n. r. | 6.9 | 4 | 5.6 | 9 |
12 months survival [%] | n. r. | 33.8 % with serum LDH < 240 15.4 % with serum LDH ≥ 240 | 25 | 24.9 | 39 |
24 months survival [%] | n.r. | n.r. | n.r. | 9.5 | 25 |