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Table 1 Clinical features of 200 Bulgarian patients with primary breast cancer selelected for age of diagnosis, family history and tumour characteristics

From: Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients

 

N

Proportion of patients per feature (%)

Age at breast cancer diagnosis

  

<40

76

38

41–60

99

49

>60

25

13

Bilateral breast cancer

  

Yes

30

15

No

170

85

Personal history of ovarian cancer

  

Yes

12

6

No

188

94

Family history of breast and ovarian cancer

  

Cancer in 1st or 2nd relative

  

Breast cancer dx < 60

73

36.5

Ovarian cancer, any age

11

5.5

Male breast cancer, any age

  

Neither

104

52

Unknown

12

6

Triple negative (TNBC)

  

Yes

28

14

No

172

86

Unknown

  

Tumor hormone receptor status

  

Estrogen receptor (ER)

  

Positive

89

45

Negative

70

34

Unknown

41

21

Pogesteron receptor (PR)

  

Positive

80

40

Negative

77

39

Unknown

43

21

Her2/neu

  

Positive

82

41

Negative

60

30

Unknown

58

29

Stage

  

1

48

24

2

103

51.5

3

15

7.5

4

1

0.5

Unknown

33

16.5

Grade

  

I

6

3

II

70

35

III

34

17

Unknown

90

45

All patients

200

100 %