Fig. 4

TRAIL receptor preference is also variable in apoptosis-sensitised pancreatic cancer cells. a TRAIL-sensitive control cells (PC-3), Panc1, Panc1.shctrl, PancTu1 and PancTu1.shctrl were treated with 10 ng/ml rTRAIL for 24 h, before apoptosis was measured. b PancTu1.shXIAP cells were treated with supernatants from HEK293 cells that were transfected with the EGFP control expression construct (ctrl; grey), sTRAIL^wt (yellow), sTRAIL^DR5–2 (light green) or sTRAIL^DR4–3 (blue-grey). After 24 h apoptosis was measured. c Panc1.shXIAP cells were treated with supernatants from HEK293 cells that were transfected with the EGFP control expression construct (ctrl; grey), sTRAIL^wt (yellow), sTRAIL^DR5–2 (light green) or sTRAIL^DR4–3 (blue-grey). After 24 h apoptosis was measured