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Table 7 Relative miRNA expression levels of 20 miRNAs in breast cancer cell lines. Results in breast cancer cell lines are expressed as the median (range) of miRNA level relative to ER- breast cancer cell lines

From: MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

Official Name

ER breast cancer cell lines (n = 19)

ER+ breast cancer cell lines (n = 11)

FC

p-value

12 miRNAs up-regulated in ER+ compared to ER breast tumors

miR-190b

1.0 (0.18-3.14)

42.9 (1.73-631)

42.99

<0.0001

miR-26a1

1.0 (0.36-3.22)

3.14 (0.36-7.83)

3.14

0.0477

miR-342-5p

1.0 (0.26-2.72)

8.24 (1.72-17.4)

8.24

<0.0001

miR-101-1

1.0 (0.50-2.54)

2.04 (0.61-6.64)

2.04

0.0111

let-7b

1.0 (0.34-4.92)

1.02 (0.01-5.24)

1.02

ns

miR-30e

1.0 (0.56-3.45)

1.50 (0.68-2.50)

1.50

ns

miR-30c2

1.0 (0.43-2.89)

0.92 (0.36-3.94)

−1.09

ns

miR-143

1.0 (0.37-36.3)

1.22 (0.37-3.84)

1.22

ns

miR-26b

1.0 (0.41-4.89)

3.54 (0.98-7.81)

3.54

0.0006

miR-376c

1.0 (0.11-22.8)

0.92 (0.00-22.1)

−1.09

ns

miR-193b

1.0 (0.26-3.90)

3.45 (0.29-12.0)

3.45

0.0052

let-7a

1.0 (0.50-2.01)

0.87 (0.10-3.61)

−1.15

ns

8 miRNAs down-regulated in ER+ compared to ER breast tumors

miR-18a

1.0 (0.15-2.39)

0.50 (0.24-25.1)

−2.00

0.0642

miR-654-3p

1.0 (0.13-9.85)

0.46 (0.24-1.93)

−2.17

ns

miR-18b

1.0 (0.17-2.45)

0.64 (0.16-27.5)

−1.56

ns

miR-155

1.0 (0.00-72.2)

0.03 (0.00-0.84)

−33.3

0.0609

miR-1244

1.0 (0.32-1.90)

0.91 (0.43-2.20)

−1.10

ns

miR-203

1.0 (0.01-10.0)

5.62 (0.03-13.3)

5.62

0.0226

miR-92a1

1.0 (0.41-2.46)

0.62 (0.35-4.29)

−1.61

0.0707

miR-146a

1.0 (0.03-91.6)

0.11 (0.03-0.25)

−9.09

0.0583

  1. The miRNAs are ranked according to the deregulation level between ER+ and ER breast tumors. For each miRNA, we report the fold-change (FC) between ER+ and ER breast cancer cell lines and the p-value associated to Mann–Whitney U test (ns for not significant)